CBD stands for cannabidiol and is also a cannabinoid. Cannabinoids are chemical compounds found in the cannabis plant. 85 cannabinoids were detected in cannabis plants. Cannabidiol, like all cannabinoids in the plant, appears as an acid. The effect of cannabidiol, however, is not psychoactive. Therefore, it does not make the sensation of getting high like THC (tetrahydrocannabinol), the most well-known and researched cannabinoid. CBD is the main non-psychoactive substance of the cannabis plant and is increasingly being investigated. However, many scientific studies that researchers have long been suspicious of and have been studying have already confirmed the great therapeutic potential of cannabis.
Liquid CBD oil containing natural cannabinoid, terpene and flavonoids is lightly extracted with organic olive oil, organic coconut oil or organic cannabis seed oil. Available in various CBD concentrations, flavors, and different bottle sizes. Drops are light, natural and have a strong cannabis flavor. If you don’t like the taste of hemp, you can try citrus or mint varieties. CBD oil is suitable for all mammals, not just dogs and cats. CBD oil has been developed specifically for dogs & cats. It is slightly mixed with olive oil because olive oil helps animals show better tolerance. The content of CBD oil for dogs & cats is the same. You can choose from different package sizes for active cannabis and active cannabis plus products with dry hemp variety with CBD.
There are also practical and tasteless CBD capsules containing 100% natural hemp in powder form. They achieve CBD quality at the same amount, 2%. For those who do not want to taste the oil, the capsule is a better choice. They are handy for traveling. There are capsules that are vegan, gluten-free and contain only 100% natural ingredients.
What is CBD Oil?
CBD oil is produced by extracting the hemp from the cannabis plant. It yields an oily extract containing various cannabinoids, which may vary depending on the storage and source, depending on the type of plant, extraction (the process of taking any substance present in one mixture from one solvent to another solvent) at different rates. Thus, an oil containing predominantly the active ingredient cannabidiol is formed, which is called CBD oil. CBD oil is available in different concentrations and for many different applications.
The human body can produce its own cannabinoids. These endogenous substances are called endocannabinoids. Some cannabinoids from the cannabis plant, including cannabidiol, are agonists. This means that by invading a receptor (protein or protein complex), they activate signaling in a particular cell. Cannabidiol from the cannabis plant acts as a hormone or neurotransmitter in the body. The difference is that it is an extra-body substance that mimics or replaces a particular messenger substance under its influence. By investigating cannabinoids, the endocannabinoid system has been discovered in the human body.
Endocannabinoid System (ECS)
The endocannabinoid system has been discovered in research on how cannabis works in the human body. More specifically, it is known which receptors in the body are affected by cannabinoids. The affected receptors are called the CB1 receptor and the CB2 receptor. These receptors are found in the body, more specifically in the brain, nervous system, organs, glands, digestive system, skin, and tissues. However, most are found in the brain. The CB1 receptor is associated, among other things, with coordination and movement, pain, emotions and mood, thinking, appetite, and memories. For example, phytocannabinoid THC is added to this receptor. CB2 receptors, respectively, affect our immune system, inflammation, and pain.
In the past, cannabidiol was thought to act directly on CB2 receptors. However, recent findings show that cannabidiol has no direct effect, but rather uses more of its cannabinoids to affect the body. The endogenous cannabinoid system contains these two receptors and is part of our nervous system. This physiological system is named after the cannabis plant and can be found in all mammals. ECS in our body is now considered one of the most important physiological systems in terms of health protection and achievement.
The most fundamental element for our body is to be in balance because it makes us feel healthy and happy. It can develop only when we are in balance. The cannabinoid receptors in the brain are responsible for the balance within the body, ie the internal balance, where the endocannabinoid system is responsible for the central and peripheral nervous system, organs, connective tissues, immune cells, glands, and digestive system. Maintaining our balance is called homeostasis in medicine.
The ECS receivers have a wireless connection throughout the body, as has been said. Regardless of the effects and fluctuations, it is exposed to, it constantly tries to regulate the body towards greater stability. Thus, the endogenous cannabinoid system supports and regulates the body in a variety of internal, physiological processes. ECS has four main tasks; These include neuroprotection (an effort to prevent the death of nerve cells), stress regeneration, immune balance, and homeostatic regulation. It helps the body among other tasks as well such as:
- pain perception
- immune function
- bone development
- motor control
Cbd Oil and Its Role
Cannabidiol is one of the most important phytocannabinoids of the cannabis plant. Cannabidiol (among others) stimulates the cannabinoid receptors CB1 and CB2 in case of instability in the body. The endocannabinoids of the body are therefore actively supported by the foreign phytocannabinoids of the cannabis plant, especially cannabidiol since they are very similar to the body’s own cannabinoids. Thus, cannabidiol oil stimulates the body itself to rearrange and stabilize. It affects the pH balance in the blood, perception of pain, regulation of appetite, mood, energy level, memory and above all the immune system. Therefore, in the case of illness, inflammation, disorders or pain in the body, taking CBD oil can be very beneficial.
As described in detail above, cannabidiol affects the endogenous cannabinoid system in humans. However, since the discovered cannabinoid system is present in all mammals (the system in animals is similar to the human system), it naturally works in animals. Most research is also done on animals. Therefore, you can also do something good for your pet (dog, cat, horse, etc.).
Properties of Cannabidiol (CBD)
Cannabidiol is said to have many therapeutic benefits because it can have low physiological and biological effects. With this report of the World Health Organization (WHO), cannabis has the following possible properties:
- anti-inflammatory (anti-inflammatory agent)
- powerful antioxidant
Numerous test reports are available to confirm the anti-inflammatory and analgesic effects of cannabidiol. In a study from the Journal of Experimental Medicine, in 2012, it was found that in mice and rats, cannabidiol can help reduce pain and reduce chronic inflammation.
In a 2013 study, it was found that smokers using an inhaler addition of hemp had fewer cigarettes and did not have many cravings for nicotine. Even in people who abuse hard drugs such as opiates, a similar study shows that cannabis can be a promising substance. The researchers also found that some of the symptoms of substance abuse can be alleviated with cannabidiol. These include anxiety, mood symptoms, pain, and insomnia. These are still very early findings, but researchers suggest that cannabidiol can be used to reduce or even prevent withdrawal symptoms.
Cannabis has been used for centuries against epilepsy. In recent years, interest has increased greatly due to high therapeutic potential. Especially in non-psychoactive hemp with anticonvulsant properties. This finding is currently supported by numerous preclinical studies. There is even a drug containing cannabidiol for epilepsy at the regulatory stage called Epidiolex.
In addition, cannabidiol can help many epilepsy-related disorders such as neurodegeneration, neuronal damage, and mental disorders. A study shows that cannabidiol has an anti-psychotic effect. Cannabidiol can therefore also help safely and effectively in schizophrenia. However, further research and hospital studies are needed to confirm this.
Of course, we have been researching hemp for cancer for a long time. According to an article in the British Journal of Pharmacology, there is evidence that cannabinoids have antitumor activity in recent years. Some reports have shown that in addition to the known beneficial effects of cannabidiol in the treatment of pain, spasticity and other diseases of the central nervous system, it inhibits antiviral, proapoptotic (triggered programmed cell death) cancer cell migration, adhesion, and invasion. Therefore, it seems to prevent the proliferation of cancer cells in the body and prevent new areas from being attacked. Furthermore, the growth of cancer cells is suppressed and their deaths are supported. Researchers believe that cannabidiol can potentially help treat cancer.
Health Benefits of Cannabidiol (CBD)
CBD is generally recommended for patients with chronic anxiety and panic attacks, because psychoactive phytocannabinoid THC may worsen. However, it is important to know that cannabidiol and THC have mutual effects. According to a 2015 review of Neurenapeutics, cannabis can help reduce anxiety in people with some anxiety disorders. The researchers point out the following studies showing that cannabidiol can reduce anxiety in the indicated anxiety disorders.
- Seasonal depression
- Obsessive-compulsive disorder (excessive thinking on rules, order, and control)
- Panic attack
- Social phobias
- Posttraumatic stress disorder
- Generalized anxiety disorder
The review in the link above also states that topical medications for these disorders can cause additional symptoms, so people can stop understanding them for sure. However, cannabidiol had no adverse effects in these cases. Accordingly, cannabidiol should now be tested more closely as a potential drug.
In the Journal of Alzheimer’s Disease, a research paper was published which demonstrated that cannabidiol seen in the experiment on mice can prevent the progression of memory loss (facial recognition) in long-term treatment. Furthermore, there are many studies showing that cannabinoids are destroying beta-amyloid plaques from brain cells, a sign of Alzheimer’s disease. Furthermore, in chronic inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis, cannabidiol appears to be a promising agent for treatment. In a study of mice, the researchers found that cannabidiol reduced inflammatory bowel inflammation.
In the evaluation of the preclinical studies conducted in 2011, it has been shown that cannabinoid-based drugs can be greatly utilized in neurodegenerative disorders affecting basal ganglia in the brain such as Parkinson’s and Huntington’s disease. This result was caused by changes in cannabinoid receptors during disease progression. The results of a double-blind trial (highest level of evidence) also show that cannabidiol has a potential effect on improving the quality of life in patients with Parkinson’s disease without psychiatric comorbidity.
Cannabidiol has an anti-inflammatory effect, which is already known. In type 1 diabetes, the body’s immune system destroys the pancreas. This is done by infiltrating the immune system cells into the islets of the pancreas in the Langerhans islets, thereby destroying insulin-producing producing cells. In simple words, the immune system attacks pancreatic cells. The trigger is inflammation of the body. Research by Clinical Hemorheology and Microcirculation 2016 found that cannabidiol can alleviate inflammation in the pancreas. The first step for a hemp-based drug.
Another promising application for hemp is acne caused by partially inflamed and over-stretched sebaceous glands. In a study published in the Journal of Clinical Investigation and the National Institute of Health, it was discovered that cannabidiol was found to help reduce sebum production by its anti-inflammatory effect.
Is it possible to use CBD oil externally in the treatment of atopic dermatitis, psoriasis, and other skin diseases? Because we cannot give advice or answer questions about the diagnosis, prevention or treatment of diseases for legal reasons, you may need to try the CBD oil yourself. External application of CBD oil to the skin is not as harmful as other oils (eg coconut oil, etc.). So you can test it yourself without any problems. However, experience reports already point to possible impacts.
The possible benefits of CBD oil used in the treatment of all listed diseases can be maintained forever. There are also studies on cannabinoids for multiple sclerosis, lupus, fibromyalgia, rheumatism, arthritis, osteoporosis, prion diseases, mad cow disease, insomnia, migraine and more. It is not right to think that the use of cannabinoid CBD oil is a miracle against all these diseases and it is necessary to be careful in such expressions. There’s more research to do. CBD oil should be considered as a useful and healthy supplement.
Side Effects of CBD Oil
The most common question that may arise when buying CBD oil is whether or not the amount of intake will make you high. A clear answer to this question should be given because CBD is a cannabinoid such as THC, but it has no hallucinogenic effect like THC. So it is not a psychoactive substance. Cannabidiol and THC have opposite effects, but they can enhance their effects together. It is even known that cannabidiol reduces the psychoactive effect of THC. Each cannabidiol oil contains at least THC traces but remains below the 0.2% legal limit. There is no concern or risk of hallucinogenic effects when taking cannabidiol oil.
Many small studies have looked at the safety of cannabidiol in adults. There is no research on children. In adults, no dangerous side effects have been seen so far. Neither on the central nervous system nor on the body’s basic functions (vital symptoms) or mood. The most commonly reported side effect in adults is fatigue. Some reported diarrhea and dry mouth, or slight changes in appetite and body weight too. At the first intake of cannabidiol oil, a slight burning may also be detected. Like eating something spicy.
Cannabidiol is a very safe substance with minor or acceptable side effects. However, you should consult naturopaths, especially when taking medication, especially in combination with very high doses of cannabidiol oil. Because of a sufficiently high dose of cannabidiol shuts off the liver enzyme cytochrome P450. This then affects how we metabolize a number of substances (including THC). Cannabidiol inhibits more than Bergapten in grapefruit. If grapefruit interacts with your medicine in any way, then this cannabis oil will probably be the same. Consult your healthcare professional before buying CBD oil.
CBD Consumption Types
Probably the best-known type of cannabinoid consumption is inhalation of cannabis. A healthier alternative might be vape pens (the name comes from vaporizing), in which cannabidiol is inhaled. However, it is important to consider that after the purchase of a vape pen, only special CBD Vape E-Fluids should be bought and used for evaporation.
However, since most patients and customers do not want to breathe anything, cannabis can now be found as capsules, drops, tinctures, and lozenges. In any case, since the substance of cannabidiol can be absorbed up to 10 times better in the body, its best effect can be achieved by oral administration. Therefore, you should confront and determine the question of whether you want to take CBD oil, CBD oil capsules or CBD oil drops. Cannabidiol oil products are available in two different dosage forms, CBD oil capsules, and CBD oil drops. Oil drop intake is tailored to the individual wishes of the customers. However, this does not make it easier to buy CBD oil, because a decision has to be made here. Should they be CBD oil drops or CBD oil capsules?
The capsules should be swallowed and the drops should be dropped under the tongue and allowed to remain in the mouth for a few minutes. Of course, CBD oil drops have a taste. If you don’t like it, you can use CBD oil capsules that don’t taste or smell. On the other hand, if you don’t want to swallow the capsules, you better use CBD oil drops. The way CBD oil is purchased is therefore only a matter of personal taste. If you don’t have a preference, you can try both of the products. Cannabidiol oil is not only taken orally but is also suitable for external use because of its excellent dermatological properties and positive effect on the skin. When buying CBD oil, it is better to choose between the options offered such as cannabis seed oil, organic olive oil or organic coconut oil and enriched cannabidiol oil.
When using CBD oil, the desired number of drops is dripped under the tongue (with a teaspoon or directly). Wait for at least 5-20 minutes after dripping CBD oil drops before drinking or eating again and allow the drops to melt under the tongue. Capsules should also be taken with plenty of water. The dosage depends on the effect you want to achieve. Also, another important thing is the level of cannabidiol concentration. The greater the concentration of cannabidiol in your drop, the fewer drops you need, since it is related to the milligram ingested.
It is recommended that you start with a low dosage and gradually increase it so that your body can gradually get used to cannabidiol. It can be used initially, for example, starting with one drop of cannabidiol per day and increasing one drop each day. Drops of CBD oil can be taken 1-3 times a day and at different times of the day. Certainly if you decide to use it only once a day at the very beginning, your choice should be in the morning or in the evening before bedtime. In the meantime, it is up to you to use drops of CBD oil or CBD oil capsules. This depends on how you feel after your use.
Pay attention to the milligrams of CBD contained in the CBD oil capsules, and you can adjust your dosage with CBD oil drops. A dosage recommendation contains in each product. Cannabidiol has no known adverse side effects, however, it should not be taken too much. Cannabidiol works in small doses and may be less effective at a very high dose. When using CBD oil, always refer to the dosage recommended for the product in the product descriptions.
The dosage for cannabidiol oil is very individual. There is no fixed dosage for everyone. After purchasing CBD oil and opened for the first time, the opened bottle is best stored in the refrigerator. Do not expose it to heat or light. The refrigerator is not necessary as long as cannabidiol oil is stored in a cool, dark environment. Usually, a bottle lasts 1-2 years after opening. You can find detailed information on the product label.
Before deciding to buy CBD oil, I want to tell you what to look for. For example, quality, cultivation and extraction methods, additives and level of cannabidiol concentration are among the important factors. In addition, accurate labeling is important, as well as laboratory tests and product analysis.
CBD Oil Products
Here are the top 3 CBD Oil products that you can buy safely:
- Herbalness – Hemp Extract Oil 1000mg for Pain, Stress & Anxiety Relief, Full Spectrum Hemp Oil, Unflavored – Anti-Inflammatory, Healthy Sleep, Mental Clarity – 1 FL oz. (30ml) Brown
2. Zen Hemp Oil Premium 500mg 60ml (2oz) – Natural Pain Reliever, Minimizes Epileptic Seizures, Cure for Anxiety, Prevents Social Recognition Deficit | Made in The USA
Price: $24.99 ($12.25 / Fl Oz)
3. Fusion Pure Hemp Oil Extract (2500mg) for Pain, Anti-Anxiety, Stress Relief – Mood Improving Hemp Oil Supplement Increase Focus and Mood – Non-GMO, Organic, Natural Hemp Oil